Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.

Alpha 1-Antitrypsin (alpha 1AT) deficiency is a hereditary disorder characterized by reduced serum levels of alpha 1AT, resulting in destruction of the lower respiratory tract by neutrophil elastase. As an approach to augment alpha 1AT levels in this disorder with physiologically normal human alpha...

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Detalhes bibliográficos
Main Authors: Garver, R I, Chytil, A, Karlsson, S, Fells, G A, Brantly, M L, Courtney, M, Kantoff, P W, Nienhuis, A W, Anderson, W F, Crystal, R G
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC304359/
https://ncbi.nlm.nih.gov/pubmed/3029759
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