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Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes.

Alpha 1-antitrypsin (alpha 1AT), a 52,000-mol-wt serum glycoprotein produced by hepatocytes and mononuclear phagocytes, functions as the major inhibitor of neutrophil elastase. The alpha 1AT haplotype S is associated with childhood liver disease and/or adult emphysema when inherited with the Z haplo...

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Detalhes bibliográficos
Main Authors: Nukiwa, T, Brantly, M, Garver, R, Paul, L, Courtney, M, LeCocq, J P, Crystal, R G
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC423375/
https://ncbi.nlm.nih.gov/pubmed/3484754
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