Chelation of intracellular calcium blocks insulin action in the adipocyte.

The hypothesis that intracellular Ca2+ is an essential component of the intracellular mechanism of insulin action in the adipocyte was evaluated. Cells were loaded with the Ca2+ chelator quin-2, by preincubating them with quin-2 AM, the tetrakis(acetoxymethyl) ester of quin-2. Quin-2 loading inhibit...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Pershadsingh, H A, Shade, D L, Delfert, D M, McDonald, J M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1987
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3103120/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.4.1025
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