Polyol Pathway Impairs the Function of SERCA and RyR in Ischemic-Reperfused Rat Hearts by Increasing Oxidative Modifications of These Proteins

A number of studies have shown that the polyol pathway, consisting of aldose reductase (AR) and sorbitol dehydrogenase (SDH), contributes to ischemia–reperfusion (I/R)-induced myocardial infarction due to depletion of ATP. In this report we show that the polyol pathway in I/R heart also contributes...

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Detalhes bibliográficos
Main Authors: Tang, Wai Ho, Kravtsov, Gennadi M., Sauert, Martina, Tong, Xiao Yong, Hou, Xiu yun, Wong, Tak Ming, Chung, Sookja K., Chung, Stephen Sum Man
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043380/
https://ncbi.nlm.nih.gov/pubmed/20025885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.12.003
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