Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress

Hyperglycemia is an indication of poor outcome for heart attack patients, even for nondiabetic patients with stress-induced hyperglycemia. Previous studies showed that inhibition of aldose reductase, the first and rate-limiting enzyme of the polyol pathway, attenuated contractile dysfunction in diab...

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Detalhes bibliográficos
Main Authors: Tang, Wai Ho, Cheng, Wing Tim, Kravtsov, Gennadi M., Tong, Xiao Yong, Hou, Xiu Yun, Chung, Sookja K., Chung, Stephen Sum Man
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Cellular and Mitochondrial Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944313/
https://ncbi.nlm.nih.gov/pubmed/20573996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00137.2010
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