State-Dependent cAMP Binding to Functioning HCN Channels Studied by Patch-Clamp Fluorometry

One major goal of ion channel research is to delineate the molecular events from the detection of the stimuli to the movement of channel gates. For ligand-gated channels, it is challenging to separate ligand binding from channel gating. Here we studied the cyclic adenosine monophosphate (cAMP)-depen...

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Bibliographische Detailangaben
Hauptverfasser: Wu, Shengjun, Vysotskaya, Zhanna V., Xu, Xinping, Xie, Changan, Liu, Qinglian, Zhou, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2011
Schlagworte:
Channels and Transporters
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043209/
https://ncbi.nlm.nih.gov/pubmed/21354395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.034
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