A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

Telomerase is tightly regulated in humans relative to mice, owing to the differential regulation of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a 160-kb transgenic bacterial artificial chromosome (BAC) spanning the hTERT locus with a Renilla luciferase (Rluc) cassette do...

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Autori principali: Jia, Wenwen, Wang, Shuwen, Horner, James W., Wang, Ning, Wang, Huayan, Gunther, Edward J., DePinho, Ronald A., Zhu, Jiyue
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2011
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042838/
https://ncbi.nlm.nih.gov/pubmed/21135040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-173989
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