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Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment

The transcription of human telomerase gene hTERT is regulated by transcription factors (TFs), including Sp1 family proteins, and its chromatin environment. To understand its regulation in a relevant chromatin context, we employed bacterial artificial chromosome reporters containing 160 kb of human g...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cheng, De, Zhao, Yuanjun, Wang, Shuwen, Jia, Wenwen, Kang, Jiuhong, Zhu, Jiyue
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706010/
https://ncbi.nlm.nih.gov/pubmed/26487723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662221
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