ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice. We presently investigated the extent to which the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zepa, Lia, Frenkel, Moran, Belinson, Haim, Kariv-Inbal, Zehavit, Kayed, Rakez, Masliah, Eliezer, Michaelson, Daniel M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: SAGE-Hindawi Access to Research 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042644/
https://ncbi.nlm.nih.gov/pubmed/21350674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/792070
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak