ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice. We presently investigated the extent to which the...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Zepa, Lia, Frenkel, Moran, Belinson, Haim, Kariv-Inbal, Zehavit, Kayed, Rakez, Masliah, Eliezer, Michaelson, Daniel M.
Formato: Artigo
Idioma:Inglês
Publicado: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042644/
https://ncbi.nlm.nih.gov/pubmed/21350674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/792070
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares