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An update on targeted gene repair in mammalian cells: methods and mechanisms

Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) has recently become a promising alternative to this method. By means of TGA, endogenous DNA...

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Autores principales: Jensen, Nanna M, Dalsgaard, Trine, Jakobsen, Maria, Nielsen, Roni R, Sørensen, Charlotte B, Bolund, Lars, Jensen, Thomas G
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042377/
https://ncbi.nlm.nih.gov/pubmed/21284895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-10
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