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PI3K/AKT Regulates Aggrecan Gene Expression by Modulating Sox9 Expression and Activity in Nucleus Pulposus Cells of the Intervertebral Disc

The goal of the investigation was to test the hypothesis that the PI3K/AKT signaling pathway regulates the expression of the major extracellular matrix component of the intervertebral disc, aggrecan, in nucleus pulposus cells. Primary rat nucleus pulposus cells were treated with PI3K inhibitor to me...

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Detalhes bibliográficos
Main Authors: Cheng, Chin-Chang, Uchiyama, Yoshiyasu, Hiyama, Akihiko, Gajghate, Sachin, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042319/
https://ncbi.nlm.nih.gov/pubmed/19711351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21904
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