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Molecular Probes of the Mechanism of Cytochrome P450. Oxygen Traps a Substrate Radical Intermediate
The diagnostic substrate tetramethylcyclopropane (TMCP) has been reexamined as a substrate with three drug- and xenobiotic-metabolizing cytochrome P450 enzymes, human CYP2E1, CYP3A4 and rat CYP2B1. The major hydroxylation product in all cases was the unrearranged primary alcohol along with smaller a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3041850/ https://ncbi.nlm.nih.gov/pubmed/21075070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.11.001 |
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