Probing the open state of cytochrome P450cam with ruthenium-linker substrates

Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Dunn, Alexander R., Dmochowski, Ivan J., Bilwes, Alexandrine M., Gray, Harry B., Crane, Brian R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60069/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221297998
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!