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Probing the open state of cytochrome P450cam with ruthenium-linker substrates
Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The National Academy of Sciences
2001
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60069/ https://ncbi.nlm.nih.gov/pubmed/11606730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221297998 |
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