Probing the open state of cytochrome P450cam with ruthenium-linker substrates
Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60069/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221297998 |
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