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Vascular actions of calcimimetics: role of Ca(2+)-sensing receptors versus Ca(2+) influx through L-type Ca(2+) channels

BACKGROUND AND PURPOSE: The calcimimetic, (R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-(1-napthyl)ethylamine hydrochloride (cinacalcet), which activates Ca(2+)-sensing receptors (CaR) in parathyroid glands, is used to treat hyperparathyroidism. Interestingly, CaR in perivascular nerves or endotheli...

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Autores principales: Thakore, Pratish, Ho, W -S Vanessa
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041262/
https://ncbi.nlm.nih.gov/pubmed/20958288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01079.x
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