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TRPML1 Channels Initiate Ca(2+) Sparks in Vascular Smooth Muscle Cells

TRPML1 (transient receptor potential mucolipin 1) is a Ca(2+)-permeable, non-selective cation channel localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma membrane. Ca(2+) released from endosomes and lysosomes into the cytosol through TRPML1 channels i...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Thakore, Pratish, Pritchard, Harry A. T., Griffin, Caoimhin S., Yamasaki, Evan, Drumm, Bernard T., Lane, Conor, Sanders, Kenton M., Earley, Yumei Feng, Earley, Scott
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397860/
https://ncbi.nlm.nih.gov/pubmed/32576680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aba1015
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