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Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility

Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in many types of cells, as typified by junctophilin-2 (JPH2), which is necessary for the formation of the cardiac dyad. Here, we report that JPH2 is the most abundant junctoph...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Pritchard, Harry A. T., Griffin, Caoimhin S., Yamasaki, Evan, Thakore, Pratish, Lane, Conor, Greenstein, Adam S., Earley, Scott
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815135/
https://ncbi.nlm.nih.gov/pubmed/31591206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911304116
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