Understanding the “lethal” drivers of tumor-stroma co-evolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor microenvironment

We have recently proposed a new model for understanding how tumors evolve. To achieve successful “Tumor-Stroma Co-Evolution”, cancer cells induce oxidative stress in adjacent fibroblasts and possibly other stromal cells. Oxidative stress in the tumor stroma mimics the effects of hypoxia, under aerob...

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Main Authors: Lisanti, Michael P, Martinez-Outschoorn, Ubaldo E, Chiavarina, Barbara, Pavlides, Stephanos, Whitaker-Menezes, Diana, Tsirigos, Aristotelis, Witkiewicz, Agnieszka, Lin, Zhao, Balliet, Renee, Howell, Anthony, Sotgia, Federica
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2010
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040943/
https://ncbi.nlm.nih.gov/pubmed/20861671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.6.13370
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