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Circular Single-Stranded Synthetic DNA Delivery Vectors for MicroRNA

Single-stranded (ss) circular oligodeoxynucleotides were previously found to undergo rolling circle transcription (RCT) by phage and bacterial RNA polymerases (RNAPs) into tandemly repetitive RNA multimers. Here, we redesign them to encode minimal primary miRNA mimics, with the long term aim of intr...

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Hlavní autoři: Seidl, Christine I., Ryan, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040211/
https://ncbi.nlm.nih.gov/pubmed/21359172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016925
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