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Circular Single-Stranded Synthetic DNA Delivery Vectors for MicroRNA

Single-stranded (ss) circular oligodeoxynucleotides were previously found to undergo rolling circle transcription (RCT) by phage and bacterial RNA polymerases (RNAPs) into tandemly repetitive RNA multimers. Here, we redesign them to encode minimal primary miRNA mimics, with the long term aim of intr...

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Autors principals: Seidl, Christine I., Ryan, Kevin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040211/
https://ncbi.nlm.nih.gov/pubmed/21359172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016925
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