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Circular Single-Stranded Synthetic DNA Delivery Vectors for MicroRNA

Single-stranded (ss) circular oligodeoxynucleotides were previously found to undergo rolling circle transcription (RCT) by phage and bacterial RNA polymerases (RNAPs) into tandemly repetitive RNA multimers. Here, we redesign them to encode minimal primary miRNA mimics, with the long term aim of intr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Seidl, Christine I., Ryan, Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040211/
https://ncbi.nlm.nih.gov/pubmed/21359172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016925
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