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Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations

The majority of inactivating mutations of p53 reside in the central core DNA binding domain of the protein. In this computational study, we investigated the structural effects of a novel p53 mutation (G389E), identified in a patient with congenital adrenal hyperplasia, which is located within the ex...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pirolli, Davide, Alinovi, Cristiana Carelli, Capoluongo, Ettore, Satta, Maria Antonia, Concolino, Paola, Giardina, Bruno, De Rosa, Maria Cristina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Molecular Diversity Preservation International (MDPI) 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039947/
https://ncbi.nlm.nih.gov/pubmed/21339981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12010128
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