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Insights from Molecular Dynamics Simulations: Structural Basis for the V567D Mutation-Induced Instability of Zebrafish Alpha-Dystroglycan and Comparison with the Murine Model

A missense amino acid mutation of valine to aspartic acid in 567 position of alpha-dystroglycan (DG), identified in dag1-mutated zebrafish, results in a reduced transcription and a complete absence of the protein. Lacking experimental structural data for zebrafish DG domains, the detailed mechanism...

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Detaylı Bibliyografya
Asıl Yazarlar: Pirolli, Davide, Sciandra, Francesca, Bozzi, Manuela, Giardina, Bruno, Brancaccio, Andrea, De Rosa, Maria Cristina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117597/
https://ncbi.nlm.nih.gov/pubmed/25078606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103866
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