Modeling the Ternary Complex TCR-Vβ/CollagenII(261–273)/HLA-DR4 Associated with Rheumatoid Arthritis

BACKGROUND: It is known that genetic predisposition to rheumatoid arthritis (RA) is associated with the MHC class II allele HLA-DR4 and that residues 261–273 of type II collagen (huCollp261) represent an immunodominant T cell epitope restricted by the DR4 molecule. Despite recent advances in charact...

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Detalhes bibliográficos
Main Authors: De Rosa, Maria Cristina, Giardina, Bruno, Bianchi, Caterina, Carelli Alinovi, Cristiana, Pirolli, Davide, Ferraccioli, Gianfranco, De Santis, Maria, Di Sante, Gabriele, Ria, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904365/
https://ncbi.nlm.nih.gov/pubmed/20644721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011550
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