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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase–linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lympho...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039848/ https://ncbi.nlm.nih.gov/pubmed/21300912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100466 |
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