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A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

To specify when and where Ig class switch recombination (CSR) takes place, a good molecular marker closely associated with active CSR is required. CSR is accompanied by deletion of circular DNA from the Ig heavy chain locus. The circular DNA contains a DNA segment between Sμ and a target S region in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kinoshita, Kazuo, Harigai, Motoko, Fagarasan, Sidonia, Muramatsu, Masamichi, Honjo, Tasuku
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606740/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221454398
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