Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo

BACKGROUND: Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are common in both superficial and invasive UC. METHODS: The effects of inhibition of receptor activity by three small molecule inhibitors (PD17307...

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Detalhes bibliográficos
Main Authors: Lamont, F R, Tomlinson, D C, Cooper, P A, Shnyder, S D, Chester, J D, Knowles, M A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039817/
https://ncbi.nlm.nih.gov/pubmed/21119661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606016
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