A Novel Small Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In Vivo

BACKGROUND: Protein kinase D (PKD) is a novel family (PKD1, PKD2, and PKD3) of serine-threonine kinases with diverse biologic functions including cell proliferation and growth. Pancreatic cancer (PaCa) is a devastating disease with few therapeutic options. We showed earlier that PKD signaling pathwa...

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Main Authors: Ireson, C.R., Harikumar, K.B., Kunnumakkara, A.B., Deorukhkar, A., Tong, Z., Jamieson, S., Sutherland, R., Raynham, T., Charles, M., Bagherzadeh, A., Farooq, M., Maru, D., Diagaradjane, P., Ochi, N., Matsuo, Y., Krishnan, S., Gelovani, J., Aggarwal, B.B., Guha, S.
Formato: Artigo
Idioma:Inglês
Publicado em: International Society of Gastrointestinal Oncology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047024/
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