A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo

Protein kinase D (PKD) family members are increasingly implicated in multiple normal and abnormal biological functions, including signaling pathways that promote mitogenesis in pancreatic cancer (PaCa). However, nothing is known about the effects of targeting PKD in PaCa. Our PKD-inhibitor discovery...

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Main Authors: Harikumar, Kuzhuvelil B., Kunnumakkara, Ajaikumar B., Ochi, Nobuo, Tong, Zhimin, Deorukhkar, Amit, Sung, Bokyung, Kelland, Lloyd, Jamieson, Stephen, Sutherland, Rachel, Raynham, Tony, Charles, Mark, Bagherazadeh, Azadeh, Foxton, Caroline, Boakes, Alexandra, Farooq, Muddasar, Maru, Dipen, Diagaradjane, Parmeswaran, Matsuo, Yoichi, Sinnett-Smith, James, Gelovani, Juri, Krishnan, Sunil, Aggarwal, Bharat B., Rozengurt, Enrique, Ireson, Christopher R., Guha, Sushovan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905628/
https://ncbi.nlm.nih.gov/pubmed/20442301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1145
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