MODL-14. SMALL MOLECULE TARGETING OF ONCOGENIC FGF2-FGFR SIGNALING IN BRAIN TUMORS

FGF2, the ligand of FGF receptors (FGFRs), is expressed in the developing and adult brain. FGF2-FGFR1 signaling causes the induction and maintenance of cancer stem cells through ERK-dependent up-regulation of ZEB1 and Olig2 in glioblastoma. In SHH medulloblastoma, Olig2 triggers tumor initiation fro...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Kumar, Karthiga Santhana, Brunner, Cyrill, Schuster, Matthias, Zerbe, Oliver, Grotzer, Michael, Schneider, Gisbert, Baumgartner, Martin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Preclinical Models/Experimental Therapy/Drug Discovery
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715438/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.588
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