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Early alterations of autophagy in Huntington disease-like mice

In a recent study, we reported in vivo evidence of early and sustained alterations of autophagy markers in a novel knock-in mouse model of Huntington disease (HD). The novel model is derived from selective breeding of HdhQ150 knock-in mice to generate mice with ∼200 CAG/polyglutamine repeats (HdhQ20...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Heng, Mary Y, Detloff, Peter J, Paulson, Henry L, Albin, Roger L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039724/
https://ncbi.nlm.nih.gov/pubmed/20935460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.6.8.13617
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