In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease

N-methyl-d-aspartate receptor (NMDAR)-mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). This hypothesis has not been tested rigorously in vivo. NMDAR–NR2B subunits are a major NR2 subunit expressed by striatal medium spiny neurons that degene...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Heng, Mary Y., Detloff, Peter J., Wang, Phillip L., Tsien, Joe Z., Albin, Roger L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666431/
https://ncbi.nlm.nih.gov/pubmed/19279257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5599-08.2009
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