Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS

Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation remain unclear. In hepatocytes, hepcidin is induced by bone morphogenetic proteins (BMPs) through a receptor complex re...

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Bibliographische Detailangaben
Hauptverfasser: Lakhal, Samira, Schödel, Johannes, Townsend, Alain R. M., Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039360/
https://ncbi.nlm.nih.gov/pubmed/20966077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173096
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