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A Novel Immunoregulatory Function for IL-23: Inhibition of IL-12 Dependent IFN-γ Production

Most studies investigating the function of IL-23 have concluded that it promotes IL-17 secreting T cells. While some reports have also characterized IL-23 as having redundant pro-inflammatory effects with IL-12, we have instead found that IL-23 antagonizes IL-12 induced secretion of IFN-γ. When sple...

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Главные авторы: Sieve, Amy N., Meeks, Karen D., Lee, Suheung, Berg, Rance E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039303/
https://ncbi.nlm.nih.gov/pubmed/20458705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939759
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