Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rβ1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, from mucocutaneous candidiasis. Susceptibility to these infections is thought to be due to impair...

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Udgivet i:Sci Immunol
Main Authors: Markle, Janet G., Martĺnez-Barricarte, Rubén, Ma, Cindy S., Deenick, Elissa K., Ramírez-Alejo, Noé, Mele, Federico, Latorre, Daniela, Mahdaviani, Seyed Alireza, Aytekin, Caner, Mansouri, Davood, Bryant, Vanessa, Jabot-Hanin, Fabienne, Deswarte, Caroline, Nieto-Patlán, Alejandro, Surace, Laura, Kerner, Gaspard, Itan, Yuval, Jovic, Sandra, Avery, Danielle T., Wong, Natalie, Rao, Geetha, Patin, Etienne, Okada, Satoshi, Bigio, Benedetta, Boisson, Bertrand, Rapaport, Franck, Seeleuthner, Yoann, Schmidt, Monika, Ikinciogullari, Aydan, Dogu, Figen, Tanir, Gonul, Tabarsi, Payam, Bloursaz, Mohammed Reza, Joseph, Julia K., Heer, Avneet, Kong, Xiao-Fei, Migaud, Mélanie, Lazarov, Tomi, Geissmann, Frédéric, Fleckenstein, Bernhard, Arlehamn, Cecilia Lindestam, Sette, Alessandro, Puel, Anne, Emile, Jean-François, van de Vosse, Esther, Quintana-Murci, Lluis, Di Santo, James P., Abel, Laurent, Boisson-Dupuis, Stéphanie, Bustamante, Jacinta, Tangye, Stuart G., Sallusto, Federica, Casanova, Jean-Laurent
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380365/
https://ncbi.nlm.nih.gov/pubmed/30578351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aau6759
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