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A mutate-and-map strategy accurately infers the base pairs of a 35-nucleotide model RNA
We present a rapid experimental strategy for inferring base pairs in structured RNAs via an information-rich extension of classic chemical mapping approaches. The mutate-and-map method, previously applied to a DNA/RNA helix, systematically searches for single mutations that enhance the chemical acce...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039151/ https://ncbi.nlm.nih.gov/pubmed/21239468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2516311 |
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