Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

Adenine-DNA glycosylase MutY of Escherichia coli catalyzes the cleavage of adenine when mismatched with 7,8-dihydro-8-oxoguanine (GO), an oxidatively damaged base. The biological outcome is the prevention of C/G→A/T transversions. The molecular mechanism of base excision repair (BER) of A/GO in mamm...

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Main Authors: Yang, Hanjing, Clendenin, Wendy M., Wong, Donny, Demple, Bruce, Slupska, Malgorzata M., Chiang, Ju-Huei, Miller, Jeffrey H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC30391/
https://ncbi.nlm.nih.gov/pubmed/11160897
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