Structure of Leishmania major Methionyl-tRNA Synthetase in Complex with Intermediate Products Methionyladenylate and Pyrophosphate

Leishmania parasites cause two million new cases of leishmaniasis each year with several hundreds of millions people at risk. Due to the paucity and shortcomings of available drugs, we have undertaken the crystal structure determination of a key enzyme from Leishmania major in hopes of creating a pl...

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Autori principali: Larson, Eric T., Kim, Jessica E., Zucker, Frank H., Kelley, Angela, Mueller, Natascha, Napuli, Alberto J., Verlinde, Christophe L.M.J., Fan, Erkang, Buckner, Frederick S., Van Voorhis, Wesley C., Merritt, Ethan A., Hol, Wim G.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039092/
https://ncbi.nlm.nih.gov/pubmed/21144880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2010.11.015
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