Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation

Common heart failure has a strong undefined heritable component. Two recent independent cardiovascular SNP array studies identified a common SNP at 1p36 in intron 2 of the HSPB7 gene as being associated with heart failure. HSPB7 resequencing identified other risk alleles but no functional gene varia...

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Detalhes bibliográficos
Main Authors: Cappola, Thomas P., Matkovich, Scot J., Wang, Wei, van Booven, Derek, Li, Mingyao, Wang, Xuexia, Qu, Liming, Sweitzer, Nancy K., Fang, James C., Reilly, Muredach P., Hakonarson, Hakon, Nerbonne, Jeanne M., Dorn, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038744/
https://ncbi.nlm.nih.gov/pubmed/21248228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017494108
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