Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation

Common heart failure has a strong undefined heritable component. Two recent independent cardiovascular SNP array studies identified a common SNP at 1p36 in intron 2 of the HSPB7 gene as being associated with heart failure. HSPB7 resequencing identified other risk alleles but no functional gene varia...

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Autori principali: Cappola, Thomas P., Matkovich, Scot J., Wang, Wei, van Booven, Derek, Li, Mingyao, Wang, Xuexia, Qu, Liming, Sweitzer, Nancy K., Fang, James C., Reilly, Muredach P., Hakonarson, Hakon, Nerbonne, Jeanne M., Dorn, Gerald W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038744/
https://ncbi.nlm.nih.gov/pubmed/21248228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017494108
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