Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease

Sporadic heart failure is thought to have a genetic component, but the contributing genetic events are poorly defined. Here, we used ultra-high-throughput resequencing of pooled DNAs to identify SNPs in 4 biologically relevant cardiac signaling genes, and then examined the association between alleli...

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Main Authors: Matkovich, Scot J., Van Booven, Derek J., Hindes, Anna, Kang, Min Young, Druley, Todd E., Vallania, Francesco L.M., Mitra, Robi D., Reilly, Muredach P., Cappola, Thomas P., Dorn, Gerald W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798680/
https://ncbi.nlm.nih.gov/pubmed/20038796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39085
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