An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

Mice with a severe genetic deficiency of protein C (PC), PC(−/−)PC(tg4), display enhanced susceptibility to lethal effects of gram-negative endotoxemia induced by lipopolysaccharide (LPS), whereas mice severely deficient in tissue factor (TF), TF(−/−)hTF(tg), are protected from LPS-mediated lethalit...

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Detalhes bibliográficos
Main Authors: Castellino, Francis J., Donahue, Deborah L., Navari, Rudolph M., Ploplis, Victoria A., Walsh, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037749/
https://ncbi.nlm.nih.gov/pubmed/20858853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-299057
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