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An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia
Mice with a severe genetic deficiency of protein C (PC), PC(−/−)PC(tg4), display enhanced susceptibility to lethal effects of gram-negative endotoxemia induced by lipopolysaccharide (LPS), whereas mice severely deficient in tissue factor (TF), TF(−/−)hTF(tg), are protected from LPS-mediated lethalit...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037749/ https://ncbi.nlm.nih.gov/pubmed/20858853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-299057 |
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