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Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia

Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (Vn) are involved in AKI. However, the functio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gupta, Kamlesh K., Donahue, Deborah L., Sandoval-Cooper, Mayra J., Castellino, Francis J., Ploplis, Victoria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370643/
https://ncbi.nlm.nih.gov/pubmed/25799354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120728
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