Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia

Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (Vn) are involved in AKI. However, the functio...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Gupta, Kamlesh K., Donahue, Deborah L., Sandoval-Cooper, Mayra J., Castellino, Francis J., Ploplis, Victoria A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370643/
https://ncbi.nlm.nih.gov/pubmed/25799354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120728
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