Peroxisome Proliferator-activated Receptor γ Negatively Regulates IFN-β Production in Toll-like Receptor (TLR) 3- and TLR4-stimulated Macrophages by Preventing Interferon Regulatory Factor 3 Binding to the IFN-β Promoter

Toll-like receptors 3 and 4 utilize adaptor TRIF to activate interferon regulatory factor 3 (IRF3), resulting in IFN-β production to mediate anti-viral and bacterial infection. Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated transcription factor expressed in various immune...

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Detalhes bibliográficos
Principais autores: Zhao, Wei, Wang, Lijuan, Zhang, Meng, Wang, Peng, Zhang, Lei, Yuan, Chao, Qi, Jianni, Qiao, Yu, Kuo, Paul C., Gao, Chengjiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037665/
https://ncbi.nlm.nih.gov/pubmed/21148557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149823
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