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Nifedipine Inhibits Cardiac Hypertrophy and Left Ventricular Dysfunction in Response to Pressure Overload

Pathological hypertrophy is commonly induced by activation of protein kinases phosphorylating class II histone deacetylases (HDACs) and de-suppression of transcription factors, such as NFAT. We hypothesized that nifedipine, an L-type Ca(2+) channel blocker, inhibits Ca(2+) -calmodulin dependent kina...

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Detalhes bibliográficos
Main Authors: Ago, Tetsuro, Yang, Yanfei, Zhai, Peiyong, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036765/
https://ncbi.nlm.nih.gov/pubmed/20559781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12265-010-9182-x
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