Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

BACKGROUND: Generation of the amyloid β (Aβ) peptide of Alzheimer's disease (AD) is differentially regulated through the intracellular trafficking of the amyloid β precursor protein (APP) within the secretory and endocytic pathways. Protein kinase C (PKC) and rho-activated coiled-coil kinases (...

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Autori principali: Lane, Rachel F, Gatson, Joshua W, Small, Scott A, Ehrlich, Michelle E, Gandy, Sam
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036620/
https://ncbi.nlm.nih.gov/pubmed/21192821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-62
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