Transient rho-associated coiled-coil containing kinase (ROCK) inhibition on human retinal pigment epithelium results in persistent Rho/ROCK downregulation

Retinal pigment epithelium (RPE) cells is the outermost layer of the retina and RPE dysfunction is a key factor in the disease pathogenesis of age-related macular degeneration (AMD). Transplantation therapy using induced pluripotent stem cell (iPSC)-derived RPEs has recently received much attention...

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Udgivet i:Biochem Biophys Rep
Main Authors: Kitahata, Shohei, Ichikawa, Hinako, Tanaka, Yuji, Inoue, Tatsuya, Kadonosono, Kazuaki
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683314/
https://ncbi.nlm.nih.gov/pubmed/33294632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100841
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