Epac2-dependent mobilization of intracellular Ca(2+) by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice

Calcium can be mobilized in pancreatic β-cells via a mechanism of Ca(2+)-induced Ca(2+) release (CICR), and cAMP-elevating agents such as exendin-4 facilitate CICR in β-cells by activating both protein kinase A and Epac2. Here we provide the first report that a novel phosphoinositide-specific phosph...

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Detalhes bibliográficos
Main Authors: Dzhura, Igor, Chepurny, Oleg G, Kelley, Grant G, Leech, Colin A, Roe, Michael W, Dzhura, Elvira, Afshari, Parisa, Malik, Sundeep, Rindler, Michael J, Xu, Xin, Lu, Youming, Smrcka, Alan V, Holz, George G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Molecular and Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036185/
https://ncbi.nlm.nih.gov/pubmed/21041529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.198424
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